Bos taurus Gene: MS4A2 | |||||||||
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Summary | |||||||||
InnateDB Gene | IDBG-638158.3 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | MS4A2 | ||||||||
Gene Name | Uncharacterized protein | ||||||||
Synonyms | |||||||||
Species | Bos taurus | ||||||||
Ensembl Gene | ENSBTAG00000020096 | ||||||||
Encoded Proteins |
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
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Protein Structure | |||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||
Entrez Gene | |||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149534:
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012] |
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Gene Information | |||||||||
Type | Protein coding | ||||||||
Genomic Location | Chromosome 15:84497142-84504751 | ||||||||
Strand | Forward strand | ||||||||
Band | |||||||||
Transcripts |
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Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||
NETPATH | |||||||||
REACTOME |
FCERI mediated NF-kB activation pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
FCERI mediated MAPK activation pathway
Innate Immune System pathway
FCERI mediated NF-kB activation pathway
Immune System pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
FCERI mediated MAPK activation pathway
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KEGG |
Fc epsilon RI signaling pathway pathway
Asthma pathway
Fc epsilon RI signaling pathway pathway
Asthma pathway
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INOH | |||||||||
PID NCI |
Fc-epsilon receptor I signaling in mast cells
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Cross-References | |||||||||
SwissProt | |||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | |||||||||
UniGene | |||||||||
RefSeq | XM_002693816 XM_610492 | ||||||||
HUGO | |||||||||
OMIM | |||||||||
CCDS | |||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | |||||||||
GenPept | |||||||||
RNA Seq Atlas | |||||||||