Version 5.4
Bos taurus Gene: ARVCF
Summary
InnateDB Gene IDBG-638161.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARVCF
Gene Name armadillo repeat protein deleted in velo-cardio-facial syndrome
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001473
Encoded Proteins
IDBP-690234
armadillo repeat protein deleted in velo-cardio-facial syndrome
IDBP-690262
armadillo repeat protein deleted in velo-cardio-facial syndrome
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099889:
Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74929359-74945937
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001929 ENSBTAP00000001929
ENSBTAT00000061101 ENSBTAP00000053343
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0016337 single organismal cell-cell adhesion
GO:0016339 calcium-dependent cell-cell adhesion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000099889
View Gene Order
ENSMUSG00000000325
View Gene Order
Cross-References
SwissProt
TrEMBL A7YY26
UniProt Splice Variant
Entrez Gene 517045
UniGene Bt.100372 Bt.104472
RefSeq NM_001105380
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149151 DAAA02045780 DAAA02045781
GenPept AAI49152
RNA Seq Atlas 517045

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca