Version 5.4
Bos taurus Gene: RAC2
Summary
InnateDB Gene IDBG-638195.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAC2
Gene Name Ras-related C3 botulinum toxin substrate 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011043
Encoded Proteins
IDBP-690247
Ras-related C3 botulinum toxin substrate 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22018470
[Homo sapiens] RAC2 is modified by Escherichia coli protein CNF1, which then interacts with the innate immune adaptors RIPK1 and RIPK2 to trigger an anti-bacterial immune response. This response was protective and increased the ability of the host to restrict pathogen growth, thus defining a mechanism of effector-triggered immunity that contributes to how metazoans defend against microbes with pathogenic potential.
PMID 22018470
[Mus musculus] Rac2 is modified by Escherichia coli protein CNF1 , which then interacts with the innate immune adaptors Ripk1 and Ripk2 to trigger an anti-bacterial immune response. This response was protective and increased the ability of the host to restrict pathogen growth, thus defining a mechanism of effector-triggered immunity that contributes to how metazoans defend against microbes with pathogenic potential. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128340:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:76033363-76050218
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014666 ENSBTAP00000014666
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0015031 protein transport
GO:0030031 cell projection assembly
GO:0030036 actin cytoskeleton organization
GO:0060263 regulation of respiratory burst
Cellular Component
GO:0005622 intracellular
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000128340
View Gene Order
ENSMUSG00000033220
View Gene Order
Pathways
NETPATH
REACTOME
REACT_211252
Sema4D in semaphorin signaling pathway
REACT_205369
Signaling by GPCR pathway
REACT_218808
Sema4D induced cell migration and growth-cone collapse pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_211150
Rho GTPase cycle pathway
REACT_214353
Signal Transduction pathway
REACT_219098
GPVI-mediated activation cascade pathway
REACT_209608
Signaling by Rho GTPases pathway
REACT_203140
Axon guidance pathway
REACT_214436
GPCR downstream signaling pathway
REACT_205384
G alpha (12/13) signalling events pathway
REACT_221457
Semaphorin interactions pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1695
GPVI-mediated activation cascade pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_19271
Semaphorin interactions pathway
REACT_11045
Signaling by Wnt pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_604
Hemostasis pathway
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_246650
Sema4D induced cell migration and growth-cone collapse pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_261444
Axon guidance pathway
REACT_210090
Rho GTPase cycle pathway
REACT_234744
Sema4D in semaphorin signaling pathway
REACT_188576
Developmental Biology pathway
REACT_263034
Semaphorin interactions pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05212
Pancreatic cancer pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05416
Viral myocarditis pathway
mmu04360
Axon guidance pathway
mmu04370
VEGF signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu04520
Adherens junction pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05212
Pancreatic cancer pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
mmu05200
Pathways in cancer pathway
mmu05416
Viral myocarditis pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
HGF signaling pathway pathway
INOH website
CD4 T cell receptor signaling pathway
INOH website
HGF signaling pathway pathway
PID NCI
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.4946
RefSeq NM_175792
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca