InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: INSIG1

Summary

InnateDB Gene

IDBG-638211.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INSIG1

Gene Name

Insulin-induced gene 1 protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001592

Encoded Proteins

IDBP-690265

Insulin-induced gene 1 protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25526307

[Homo sapiens] Upon cytoplasmic DNA stimulation, the endoplasmic reticulum protein AMFR is recruited to and interacts with TMEM173 in an INSIG1-dependent manner.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186480:
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:117906798-117920021

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002084

ENSBTAP00000002084

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006695	cholesterol biosynthetic process
GO:0006991	response to sterol depletion
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0010894	negative regulation of steroid biosynthetic process
GO:0016126	sterol biosynthetic process
GO:0032933	SREBP signaling pathway
GO:0042472	inner ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0045599	negative regulation of fat cell differentiation
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0060021	palate development
GO:0060363	cranial suture morphogenesis
GO:1901303	negative regulation of cargo loading into COPII-coated vesicle

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032937	SREBP-SCAP-Insig complex