Version 5.4
Bos taurus Gene: EXOSC1
Summary
InnateDB Gene IDBG-638229.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOSC1
Gene Name exosome complex component CSL4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012699
Encoded Proteins
IDBP-690286
3'-5' exoribonuclease CSL4 homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171311:
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:18522299-18528929
Strand Reverse strand
Band
Transcripts
ENSBTAT00000016879 ENSBTAP00000016879
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000171311
View Gene Order
ENSMUSG00000034321
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24915
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_25042
KSRP destabilizes mRNA pathway
REACT_20619
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_17015
Metabolism of proteins pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
REACT_252013
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_198696
KSRP destabilizes mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03018
RNA degradation pathway
mmu03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5E9E9
UniProt Splice Variant
Entrez Gene 506018
UniGene
RefSeq NM_001015529
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133440 BT020971 DAAA02058916
GenPept AAI33441 AAX08988
RNA Seq Atlas 506018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca