Version 5.4
Bos taurus Gene: BT.21547
Summary
InnateDB Gene IDBG-638338.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.21547
Gene Name plakophilin-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002651
Encoded Proteins
IDBP-690412
plakophilin-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057294:
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:77370781-77452340
Strand Forward strand
Band
Transcripts
ENSBTAT00000003435 ENSBTAP00000003435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005488 binding
GO:0005515 protein binding
GO:0019215 intermediate filament binding
GO:0032947 protein complex scaffold
Biological Process
GO:0002159 desmosome assembly
GO:0007507 heart development
GO:0016337 single organismal cell-cell adhesion
GO:0045110 intermediate filament bundle assembly
GO:0048496 maintenance of organ identity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086019 cell-cell signaling involved in cardiac conduction
GO:0086069 bundle of His cell to Purkinje myocyte communication
GO:0086091 regulation of heart rate by cardiac conduction
Cellular Component
GO:0005634 nucleus
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0014704 intercalated disc
GO:0030054 cell junction
GO:0030057 desmosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000057294
View Gene Order
ENSMUSG00000041957
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.21547
RefSeq NM_001083729 XM_005206843
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca