InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALAD

Summary

InnateDB Gene

IDBG-638350.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALAD

Gene Name

Delta-aminolevulinic acid dehydratase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000251

Encoded Proteins

IDBP-690414

Delta-aminolevulinic acid dehydratase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148218:
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:104342905-104352825

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000315

ENSBTAP00000000315

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004655	porphobilinogen synthase activity
GO:0008270	zinc ion binding
GO:0016829	lyase activity
GO:0032791	lead ion binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0008152	metabolic process
GO:0033014	tetrapyrrole biosynthetic process
GO:0051260	protein homooligomerization
GO:0071353	cellular response to interleukin-4