InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Alad

Summary

InnateDB Gene

IDBG-153421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alad

Gene Name

aminolevulinate, delta-, dehydratase

Synonyms

ALADH; Lv

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028393

Encoded Proteins

IDBP-153423

aminolevulinate, delta-, dehydratase

IDBP-266659

aminolevulinate, delta-, dehydratase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148218:
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:62509169-62519918

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030090	ENSMUSP00000030090
ENSMUST00000107444	ENSMUSP00000103068
ENSMUST00000137448

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004655	porphobilinogen synthase activity
GO:0008270	zinc ion binding
GO:0032791	lead ion binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0033014	tetrapyrrole biosynthetic process
GO:0051260	protein homooligomerization
GO:0071353	cellular response to interleukin-4