Version 5.4
Bos taurus Gene: CPSF3
Summary
InnateDB Gene IDBG-638377.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPSF3
Gene Name Cleavage and polyadenylation specificity factor subunit 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019735
Encoded Proteins
IDBP-690440
Cleavage and polyadenylation specificity factor subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119203:
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:87960693-87994179
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026303 ENSBTAP00000026303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004521 endoribonuclease activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0006398 histone mRNA 3'-end processing
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000119203
View Gene Order
ENSMUSG00000054309
View Gene Order
Pathways
NETPATH
REACTOME
REACT_209718
RNA Polymerase II Transcription pathway
REACT_224643
Cleavage of Growing Transcript in the Termination Region pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_204974
Processing of Capped Intronless Pre-mRNA pathway
REACT_203211
mRNA 3'-end processing pathway
REACT_224602
Transport of Mature Transcript to Cytoplasm pathway
REACT_224606
RNA Polymerase II Transcription Termination pathway
REACT_207634
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_226022
Gene Expression pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_225642
Processing of Intronless Pre-mRNAs pathway
REACT_210287
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1096
Processing of Intronless Pre-mRNAs pathway
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1835
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_1768
Processing of Capped Intronless Pre-mRNA pathway
REACT_338
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_240247
mRNA 3'-end processing pathway
REACT_237682
Transport of Mature Transcript to Cytoplasm pathway
REACT_249110
mRNA Splicing pathway
REACT_248407
Processing of Capped Intronless Pre-mRNA pathway
REACT_232123
Processing of Intronless Pre-mRNAs pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_244199
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_250734
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
hsa03015
mRNA surveillance pathway pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt P79101
TrEMBL
UniProt Splice Variant
Entrez Gene 281712
UniGene Bt.5045
RefSeq NM_174284 XM_005212921
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104553 X95906
GenPept AAI04554 CAA65151
RNA Seq Atlas 281712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca