Version 5.4
Bos taurus Gene: HSD11B1
Summary
InnateDB Gene IDBG-638384.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD11B1
Gene Name corticosteroid 11-beta-dehydrogenase isozyme 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015086
Encoded Proteins
IDBP-690445
corticosteroid 11-beta-dehydrogenase isozyme 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117594:
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:75463612-75508770
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020078 ENSBTAP00000020078
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0008152 metabolic process
GO:0030324 lung development
GO:0055114 oxidation-reduction process
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000117594
View Gene Order
ENSMUSG00000016194
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11036
Glucocorticoid biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
REACT_207160
Glucocorticoid biosynthesis pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_220061
Metabolism of steroid hormones and vitamin D pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
mmu00980
Metabolism of xenobiotics by cytochrome P450 pathway
mmu00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001123032
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca