Version 5.4
Bos taurus Gene: PAFAH1B3
Summary
InnateDB Gene IDBG-638564.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAFAH1B3
Gene Name Platelet-activating factor acetylhydrolase IB subunit gamma
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019787
Encoded Proteins
IDBP-690637
Platelet-activating factor acetylhydrolase IB subunit gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079462:
This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with mental retardation, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:51308584-51311417
Strand Forward strand
Band
Transcripts
ENSBTAT00000026366 ENSBTAP00000026366
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007283 spermatogenesis
GO:0016042 lipid catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000079462
View Gene Order
ENSMUSG00000005447
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00565
Ether lipid metabolism pathway
mmu00565
Ether lipid metabolism pathway
INOH
PID NCI
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt Q29460
TrEMBL
UniProt Splice Variant
Entrez Gene 282515
UniGene Bt.4040
RefSeq NM_174665 XM_005219169 XM_005219170 XM_005219172
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120202 D30789
GenPept AAI20203 BAA06455
RNA Seq Atlas 282515

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca