InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTGS1

Summary

InnateDB Gene

IDBG-638565.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGS1

Gene Name

Prostaglandin G/H synthase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006716

Encoded Proteins

IDBP-690641

Prostaglandin G/H synthase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095303:
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:93219287-93245045

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008833

ENSBTAP00000008833

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0004666	prostaglandin-endoperoxide synthase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006693	prostaglandin metabolic process
GO:0006979	response to oxidative stress
GO:0008217	regulation of blood pressure
GO:0019371	cyclooxygenase pathway
GO:0042127	regulation of cell proliferation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0031090	organelle membrane
GO:0043231	intracellular membrane-bounded organelle