Version 5.4
Homo sapiens Gene: PTGS1
Summary
InnateDB Gene IDBG-83887.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGS1
Gene Name prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Synonyms COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS
Species Homo sapiens
Ensembl Gene ENSG00000095303
Encoded Proteins
IDBP-83889
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
IDBP-83891
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
IDBP-83893
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
IDBP-379645
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
IDBP-603420
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
IDBP-807494
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
IDBP-807510
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:122370530-122395703
Strand Forward strand
Band q33.2
Transcripts
ENST00000362012 ENSP00000354612
ENST00000223423 ENSP00000223423
ENST00000373698 ENSP00000362802
ENST00000426608 ENSP00000411606
ENST00000540753 ENSP00000437709
ENST00000614910 ENSP00000484800
ENST00000619306 ENSP00000483540
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005515 protein binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006629 lipid metabolic process
GO:0006693 prostaglandin metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006979 response to oxidative stress
GO:0008217 regulation of blood pressure
GO:0019369 arachidonic acid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0042127 regulation of cell proliferation
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047250
View Gene Order
ENSBTAG00000006716
Not yet available
Pathways
NETPATH
REACTOME
REACT_150149
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_1396
COX reactions pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000962 NM_001271164 NM_001271165 NM_001271166 NM_001271367 NM_001271368 NM_080591 XM_005252105 XM_006717192
HUGO
OMIM
CCDS CCDS59520 CCDS59521 CCDS6842 CCDS6843 CCDS75895
HPRD 07518
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca