Homo sapiens Gene: PTGS1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-83887.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PTGS1 | ||||||||||||||||||||||
Gene Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | ||||||||||||||||||||||
Synonyms | COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000095303 | ||||||||||||||||||||||
Encoded Proteins |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012] This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 9:122370530-122395703 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q33.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
Arachidonic acid metabolism pathway
COX reactions pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
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KEGG |
Arachidonic acid metabolism pathway
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INOH |
Prostaglandin Leukotriene metabolism pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_000962 NM_001271164 NM_001271165 NM_001271166 NM_001271367 NM_001271368 NM_080591 XM_005252105 XM_006717192 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS59520 CCDS59521 CCDS6842 CCDS6843 CCDS75895 | ||||||||||||||||||||||
HPRD | 07518 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||