InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SGCA

Summary

InnateDB Gene

IDBG-638659.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SGCA

Gene Name

alpha-sarcoglycan precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003956

Encoded Proteins

IDBP-690749

alpha-sarcoglycan

IDBP-690754

alpha-sarcoglycan

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108823:
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:37113477-37122446

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005180	ENSBTAP00000005180
ENSBTAT00000043279	ENSBTAP00000040861

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0006936	muscle contraction
GO:0007517	muscle organ development

Cellular Component

GO:0005911	cell-cell junction
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016011	dystroglycan complex
GO:0016012	sarcoglycan complex
GO:0016020	membrane
GO:0042383	sarcolemma
GO:0045121	membrane raft