Version 5.4
Mus musculus Gene: Sgca
Summary
InnateDB Gene IDBG-209323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgca
Gene Name sarcoglycan, alpha (dystrophin-associated glycoprotein)
Synonyms 50DAG; Asg
Species Mus musculus
Ensembl Gene ENSMUSG00000001508
Encoded Proteins
IDBP-209325
sarcoglycan, alpha (dystrophin-associated glycoprotein)
IDBP-209327
sarcoglycan, alpha (dystrophin-associated glycoprotein)
IDBP-541008
sarcoglycan, alpha (dystrophin-associated glycoprotein)
IDBP-533489
sarcoglycan, alpha (dystrophin-associated glycoprotein)
IDBP-623452
sarcoglycan, alpha (dystrophin-associated glycoprotein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sarcoglycan alpha/epsilon family of transmembrane proteins. The encoded protein is part of the dystrophin-glycoprotein complex which links the extracellular matrix to the cytoskeleton in muscle fibers. Disruption of this gene results in progressive muscular dystrophy and is associated with the development of embryonal rhabdomysarcoma. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:94962791-94976327
Strand Reverse strand
Band D
Transcripts
ENSMUST00000103162 ENSMUSP00000099451
ENSMUST00000100551 ENSMUSP00000098118
ENSMUST00000139855 ENSMUSP00000117637
ENSMUST00000152042 ENSMUSP00000118455
ENSMUST00000166320 ENSMUSP00000130617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0006936 muscle contraction
GO:0007517 muscle organ development
GO:0061024 membrane organization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016011 dystroglycan complex
GO:0016012 sarcoglycan complex
GO:0016020 membrane
GO:0042383 sarcolemma
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108823
View Gene Order
ENSBTAG00000003956
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu05416
Viral myocarditis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05416
Viral myocarditis pathway
INOH
PID NCI
Cross-References
SwissProt P82350
TrEMBL Q5SWB0 Q5SWB4
UniProt Splice Variant
Entrez Gene 20391
UniGene Mm.18709 Mm.406631
RefSeq NM_009161 NM_001136080
OMIM
CCDS CCDS25266
HPRD
IMGT
MGI ID MGI:894698
MGI Symbol Sgca
EMBL AB024920 AF019564 AF064081 AK075915 AL606480
GenPept AAB70754 AAC33447 BAA83491 BAC36051
RNA Seq Atlas 20391

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca