InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ITGA3

Summary

InnateDB Gene

IDBG-638685.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA3

Gene Name

Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain

Synonyms

GAPB3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019498

Encoded Proteins

IDBP-690793

Integrin alpha-3Integrin alpha-3 heavy chainIntegrin alpha-3 light chain

IDBP-690834

Integrin alpha-3Integrin alpha-3 heavy chainIntegrin alpha-3 light chain

IDBP-690839

Integrin alpha-3Integrin alpha-3 heavy chainIntegrin alpha-3 light chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20877569

[Homo sapiens] ITGA3 along with ITGB1 is a novel regulator for the recognition of bacterial lipopeptides. ITGA3/ITGB1 integrin regulates endosomal Toll-like receptor (TLR)-2/TLR1 signalling, serving as a mechanism for modulating inflammatory responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005884:
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:37198628-37231287

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000054196	ENSBTAP00000050366
ENSBTAT00000025974	ENSBTAP00000025974
ENSBTAT00000057592	ENSBTAP00000047798

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007613	memory

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0043235	receptor complex
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome