InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ITGA3

Summary

InnateDB Protein

IDBP-690834.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA3

Protein Name

Integrin alpha-3Integrin alpha-3 heavy chainIntegrin alpha-3 light chain

Synonyms

GAPB3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025974

InnateDB Gene

IDBG-638685 (ITGA3)

Protein Structure

UniProt Annotation

Function

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007613	memory

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0043235	receptor complex
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome