InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.74188

Summary

InnateDB Gene

IDBG-638745.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.74188

Gene Name

class E basic helix-loop-helix protein 41

Synonyms

BHLHB3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030575

Encoded Proteins

IDBP-690855

basic helix-loop-helix domain containing, class B, 3

IDBP-690859

basic helix-loop-helix domain containing, class B, 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL\'s transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:84233719-84236923

Strand

Forward strand

Band

Transcripts

ENSBTAT00000043182	ENSBTAP00000040772
ENSBTAT00000063451	ENSBTAP00000054651

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043425	bHLH transcription factor binding
GO:0043426	MRF binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007623	circadian rhythm
GO:0010832	negative regulation of myotube differentiation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0032922	circadian regulation of gene expression
GO:0045892	negative regulation of transcription, DNA-templated