Version 5.4
Mus musculus Gene: Bhlhe41
Summary
InnateDB Gene IDBG-197884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bhlhe41
Gene Name basic helix-loop-helix family, member e41
Synonyms 6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2; Sharp1
Species Mus musculus
Ensembl Gene ENSMUSG00000030256
Encoded Proteins
IDBP-197886
basic helix-loop-helix family, member e41
IDBP-257605
basic helix-loop-helix family, member e41
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a class E basic helix-loop-helix type transcription factor. The encoded protein is a key regulator of the mammalian circadian clock. A dominant mutation in this gene results in a short sleep phenotype. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl\'s transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:145858243-145865558
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000032386 ENSMUSP00000032386
ENSMUST00000111703 ENSMUSP00000107332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001191 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043425 bHLH transcription factor binding
GO:0043426 MRF binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007623 circadian rhythm
GO:0010832 negative regulation of myotube differentiation
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0032922 circadian regulation of gene expression
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005654 nucleoplasm
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123095
View Gene Order
ENSBTAG00000030575
Not yet available
Pathways
NETPATH
REACTOME
REACT_115781
Bmal1:Clock,Npas2 activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_200794
Mus musculus biological processes pathway
REACT_241925
Circadian Clock pathway
REACT_198620
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
KEGG
mmu04710
Circadian rhythm pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_24941
Circadian Clock pathway
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL D3Z2G6
UniProt Splice Variant
Entrez Gene 79362
UniGene Mm.154529 Mm.396926 Mm.400172 Mm.407866
RefSeq NM_001271768 NM_024469 XM_006507013
OMIM
CCDS CCDS71860 CCDS20697
HPRD
IMGT
MGI ID MGI:1930704
MGI Symbol Bhlhe41
EMBL AC144936
GenPept
RNA Seq Atlas 79362

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca