InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CTPS2

Summary

InnateDB Gene

IDBG-638838.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTPS2

Gene Name

CTP synthase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017017

Encoded Proteins

IDBP-690949

CTP synthase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047230:
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:134046108-134155813

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022629

ENSBTAP00000022629

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003883	CTP synthase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016874	ligase activity