Version 5.4
| Mus musculus Gene: Ctps2 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-183964.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Ctps2 | ||||||||||||||||||||||
| Gene Name | cytidine 5'-triphosphate synthase 2 | ||||||||||||||||||||||
| Synonyms | A830031M15Rik; AI326475; Ctpsh | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000031360 | ||||||||||||||||||||||
| Encoded Proteins |
cytidine 5'-triphosphate synthase 2
cytidine 5'-triphosphate synthase 2
cytidine 5'-triphosphate synthase 2
cytidine 5'-triphosphate synthase 2
cytidine 5'-triphosphate synthase 2
cytidine 5'-triphosphate synthase 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047230:
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jan 2009] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome X:162901238-163032508 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | F4 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Synthesis and interconversion of nucleotide di- and triphosphates pathway
Metabolism pathway
Metabolism of nucleotides pathway
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| KEGG |
Pyrimidine metabolism pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Synthesis and interconversion of nucleotide di- and triphosphates pathway
Metabolism of nucleotides pathway
Metabolism pathway
Metabolism of nucleotides pathway
Metabolism pathway
Synthesis and interconversion of nucleotide di- and triphosphates pathway
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| KEGG |
Pyrimidine metabolism pathway
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| INOH |
Pyrimidine nucleotides nucleosides metabolism pathway
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| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | P70303 | ||||||||||||||||||||||
| TrEMBL | A2AEQ5 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 55936 | ||||||||||||||||||||||
| UniGene | Mm.2065 Mm.400549 | ||||||||||||||||||||||
| RefSeq | NM_001168568 XM_006528911 XM_006528912 XM_006528913 XM_006528914 XM_006528915 NM_001168569 NM_001168571 NM_018737 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS41202 CCDS53240 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:1933185 | ||||||||||||||||||||||
| MGI Symbol | Ctps2 | ||||||||||||||||||||||
| EMBL | AK032018 AK052854 AK084595 AK150966 AK151597 AK161564 AK164206 AL671975 AL807822 BC003257 U49385 | ||||||||||||||||||||||
| GenPept | AAB17729 AAH03257 BAC27651 BAC35174 BAC39223 BAE29997 BAE30537 BAE36466 BAE37683 | ||||||||||||||||||||||
| RNA Seq Atlas | 55936 | ||||||||||||||||||||||