InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LRSAM1

Summary

InnateDB Gene

IDBG-638929.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRSAM1

Gene Name

E3 ubiquitin-protein ligase LRSAM1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012844

Encoded Proteins

IDBP-691049

E3 ubiquitin-protein ligase LRSAM1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148356:
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:98196090-98229896

Strand

Forward strand

Band

Transcripts

ENSBTAT00000017067

ENSBTAP00000017067

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0030163	protein catabolic process
GO:0045806	negative regulation of endocytosis
GO:0046755	non-lytic virus budding
GO:0051865	protein autoubiquitination
GO:0070086	ubiquitin-dependent endocytosis