Version 5.4
Bos taurus Gene: CBX1
Summary
InnateDB Gene IDBG-638942.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBX1
Gene Name chromobox protein homolog 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002949
Encoded Proteins
IDBP-691052
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108468:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39032381-39051471
Strand Forward strand
Band
Transcripts
ENSBTAT00000003835 ENSBTAP00000056404
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:1990226 histone methyltransferase binding
Biological Process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005721 centromeric heterochromatin
GO:0005819 spindle
GO:0010369 chromocenter
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000108468
View Gene Order
ENSMUSG00000018666
View Gene Order
Cross-References
SwissProt
TrEMBL G5E6N7 Q52T72
UniProt Splice Variant
Entrez Gene 616506
UniGene Bt.62437
RefSeq NM_001206415 XM_005199210 XM_005210186 XM_005220624 XM_005220626
HUGO HGNC:1551
OMIM
CCDS
HPRD
IMGT
EMBL AY962097 DAAA02049074
GenPept AAX94032
RNA Seq Atlas 101904753 616506

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca