InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cbx1

Summary

InnateDB Gene

IDBG-209987.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbx1

Gene Name

chromobox 1

Synonyms

Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta; M31; MOD1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018666

Encoded Proteins

IDBP-209989

chromobox homolog 1 (Drosophila HP1 beta)

IDBP-209991

chromobox homolog 1 (Drosophila HP1 beta)

IDBP-209993

chromobox homolog 1 (Drosophila HP1 beta)

IDBP-718720

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108468:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:96789127-96808640

Strand

Forward strand

Band

Transcripts

ENSMUST00000093943	ENSMUSP00000091475
ENSMUST00000079702	ENSMUSP00000078640
ENSMUST00000018810	ENSMUSP00000018810
ENSMUST00000134585	ENSMUSP00000137834
ENSMUST00000141257

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	59 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:1990226	histone methyltransferase binding

Biological Process

GO:0045892

negative regulation of transcription, DNA-templated

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000785	chromatin
GO:0001939	female pronucleus
GO:0001940	male pronucleus
GO:0005634	nucleus
GO:0005721	centromeric heterochromatin
GO:0005819	spindle
GO:0010369	chromocenter

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000108468

View Gene Order

ENSBTAG00000002949

Not yet available

Cross-References

SwissProt

P83917

TrEMBL

Q7TPM0 Q9CYJ8

UniProt Splice Variant

Entrez Gene

12412

UniGene

Mm.29055 Mm.415754

RefSeq

NM_007622 XM_006532099 XM_006532100

OMIM

CCDS

CCDS25303

HPRD

IMGT

MGI ID

MGI:105369

MGI Symbol

Cbx1

EMBL

AK014215 AK017608 AL596384 BC055290 CH466556 X56690

GenPept

AAH55290 BAB29211 BAB30836 CAA40018 EDL16045

RNA Seq Atlas

12412