Version 5.4
Bos taurus Gene: SH2B1
Summary
InnateDB Gene IDBG-638958.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2B1
Gene Name SH2B adapter protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019219
Encoded Proteins
IDBP-691076
SH2B adaptor protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178188:
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:26208972-26214950
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025587 ENSBTAP00000025587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0030032 lamellipodium assembly
GO:0035556 intracellular signal transduction
GO:0045840 positive regulation of mitosis
GO:2000278 regulation of DNA biosynthetic process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000178188
View Gene Order
ENSMUSG00000030733
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_22
Leptin pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_200794
Mus musculus biological processes pathway
REACT_224553
Hemostasis pathway
REACT_198561
Prolactin receptor signaling pathway
REACT_169390
Signaling by Leptin pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_198614
Growth hormone receptor signaling pathway
REACT_188257
Signal Transduction pathway
REACT_188529
Signaling by Leptin pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MJV1 G8CY04
UniProt Splice Variant
Entrez Gene 506066
UniGene Bt.24389
RefSeq NM_001205529 XM_005224862 XM_005224863 XM_005224864
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057886 HQ418502
GenPept AEP14550
RNA Seq Atlas 506066

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca