InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MID1

Summary

InnateDB Gene

IDBG-639068.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MID1

Gene Name

midline-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010152

Encoded Proteins

IDBP-691187

midline 1 (Opitz/BBB syndrome)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] MID1 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101871:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:139791005-139928580

Strand

Forward strand

Band

Transcripts

ENSBTAT00000013398

ENSBTAP00000013398

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0007026	negative regulation of microtubule depolymerization
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0035372	protein localization to microtubule

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0015630	microtubule cytoskeleton

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000101871

View Gene Order

ENSMUSG00000035299

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

mmu04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1BAD8

UniProt Splice Variant

Entrez Gene

534604

UniGene

Bt.58809

RefSeq

NM_001192822 XM_005228472 XM_005228473 XM_005228474 XM_005228475 XM_005228476 XM_005228477

HUGO

HGNC:7095

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02075420

GenPept

RNA Seq Atlas

534604