Version 5.4
Mus musculus Gene: Mid1
Summary
InnateDB Gene IDBG-186021.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mid1
Gene Name midline 1
Synonyms 61B3-R; DXHXS1141; Fxy; Trim18
Species Mus musculus
Ensembl Gene ENSMUSG00000035299
Encoded Proteins
IDBP-186023
midline 1
IDBP-186025
midline 1
IDBP-186027
midline 1
IDBP-256693
midline 1
IDBP-256695
midline 1
IDBP-256697
midline 1
IDBP-627191
midline 1
IDBP-627192
midline 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23438823
[Homo sapiens] MID1 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101871:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:169685199-170005736
Strand Forward strand
Band F5
Transcripts
ENSMUST00000078947 ENSMUSP00000077974
ENSMUST00000036753 ENSMUSP00000038765
ENSMUST00000079443 ENSMUSP00000078412
ENSMUST00000112107 ENSMUSP00000107735
ENSMUST00000112105 ENSMUSP00000107733
ENSMUST00000112104 ENSMUSP00000107732
ENSMUST00000149258
ENSMUST00000133857
ENSMUST00000146073
ENSMUST00000152163
ENSMUST00000129642
ENSMUST00000151722
ENSMUST00000143815
ENSMUST00000171433 ENSMUSP00000126746
ENSMUST00000163810 ENSMUSP00000128176
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0051219 phosphoprotein binding
Biological Process
GO:0007026 negative regulation of microtubule depolymerization
GO:0008152 metabolic process
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0035372 protein localization to microtubule
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101871
View Gene Order
ENSBTAG00000010152
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.34441 Mm.474237
RefSeq NM_001290504 NM_001290505 NM_001290506 NM_001290512 NM_010797 NM_183151 XM_006528729 XM_006528730 XM_006528733 XM_006528737
OMIM
CCDS CCDS41215
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca