Version 5.4
Bos taurus Gene: ABHD12
Summary
InnateDB Gene IDBG-639202.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABHD12
Gene Name Monoacylglycerol lipase ABHD12
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001420
Encoded Proteins
IDBP-691345
Monoacylglycerol lipase ABHD12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100997:
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:43187469-43240717
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001863 ENSBTAP00000001863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0047372 acylglycerol lipase activity
Biological Process
GO:0006660 phosphatidylserine catabolic process
GO:0007628 adult walking behavior
GO:0010996 response to auditory stimulus
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100997
View Gene Order
ENSMUSG00000032046
View Gene Order
Cross-References
SwissProt Q08DW9
TrEMBL
UniProt Splice Variant
Entrez Gene 768242
UniGene Bt.2203
RefSeq NM_001078116
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123534
GenPept AAI23535
RNA Seq Atlas 768242

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca