Version 5.4
Mus musculus Gene: Abhd12
Summary
InnateDB Gene IDBG-209406.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abhd12
Gene Name abhydrolase domain containing 12
Synonyms 1500011G07Rik; 6330583M11Rik; AI431047; AW547313
Species Mus musculus
Ensembl Gene ENSMUSG00000032046
Encoded Proteins
IDBP-209410
abhydrolase domain containing 12
IDBP-538044
abhydrolase domain containing 12
IDBP-535201
abhydrolase domain containing 12
IDBP-534410
abhydrolase domain containing 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100997:
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:150832493-150904741
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000056149 ENSMUSP00000053558
ENSMUST00000156641
ENSMUST00000141899 ENSMUSP00000122763
ENSMUST00000145826 ENSMUSP00000122331
ENSMUST00000138608
ENSMUST00000155119
ENSMUST00000129228 ENSMUSP00000118501
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0047372 acylglycerol lipase activity
Biological Process
GO:0006660 phosphatidylserine catabolic process
GO:0007628 adult walking behavior
GO:0008152 metabolic process
GO:0010996 response to auditory stimulus
Cellular Component
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100997
View Gene Order
ENSBTAG00000001420
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_024465 XM_006500365
OMIM
CCDS CCDS50742
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca