Version 5.4
Bos taurus Gene: PROC
Summary
InnateDB Gene IDBG-639221.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROC
Gene Name vitamin K-dependent protein C precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003950
Encoded Proteins
IDBP-691356
vitamin K-dependent protein C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115718:
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:5034439-5044966
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005163 ENSBTAP00000005163
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115718
View Gene Order
ENSMUSG00000024386
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_326
Intrinsic Pathway pathway
REACT_1439
Common Pathway pathway
REACT_1050
Gamma-carboxylation of protein precursors pathway
REACT_1906
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_733
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_1132
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_245393
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_239392
Intrinsic Pathway pathway
REACT_235097
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_235159
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_254191
Gamma-carboxylation of protein precursors pathway
REACT_229541
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_255710
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_259461
Common Pathway pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
mmu04610
Complement and coagulation cascades pathway
INOH
PID NCI
integrin2_pathway
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 281428
UniGene
RefSeq NM_001166512 XM_005202188 XM_005202189 XM_005202190
HUGO HGNC:9451
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 281428

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca