Version 5.4
Bos taurus Gene: PPP4C
Summary
InnateDB Gene IDBG-639225.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP4C
Gene Name Serine/threonine-protein phosphatase 4 catalytic subunit
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012928
Encoded Proteins
IDBP-691359
Serine/threonine-protein phosphatase 4 catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18634786
[Homo sapiens] PPP4C negatively regulates lipopolysacharide (LPS)-induced and TRAF6-mediated NF-kappaB activation by inhibiting the ubiquitination of TRAF6.
PMID 26363053
[Mus musculus] Ppp4c, a serine/threonine phosphatase, directly binds to Tbk1 upon virus infection to dephosphorylate Tbk1 and inhibit Tbk1 activation, and subsequently restrain Irf3 activation, resulting in suppressed production of type I IFN and IFN-stimulated genes.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149923:
Gene Information
Type Protein coding
Genomic Location Chromosome 25:26460142-26468245
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017178 ENSBTAP00000017178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030289 protein phosphatase 4 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000149923
View Gene Order
ENSMUSG00000030697
View Gene Order
Cross-References
SwissProt A6H772
TrEMBL
UniProt Splice Variant
Entrez Gene 540398
UniGene Bt.42027
RefSeq NM_001099108 XM_005224947 XM_005224948
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146137
GenPept AAI46138
RNA Seq Atlas 540398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca