Version 5.4
Homo sapiens Gene: PPP4C
Summary
InnateDB Gene IDBG-25572.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP4C
Gene Name protein phosphatase 4, catalytic subunit
Synonyms PP4; PP4C; PPH3; PPP4; PPX
Species Homo sapiens
Ensembl Gene ENSG00000149923
Encoded Proteins
IDBP-25574
protein phosphatase 4, catalytic subunit
IDBP-749889
IDBP-745625
IDBP-745929
IDBP-753910
IDBP-749687
IDBP-745951
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18634786
PPP4C negatively regulates lipopolysacharide (LPS)-induced and TRAF6-mediated NF-kappaB activation by inhibiting the ubiquitination of TRAF6.
InnateDB Annotation from Orthologs
Summary
PMID 26363053
[Mus musculus] Ppp4c, a serine/threonine phosphatase, directly binds to Tbk1 upon virus infection to dephosphorylate Tbk1 and inhibit Tbk1 activation, and subsequently restrain Irf3 activation, resulting in suppressed production of type I IFN and IFN-stimulated genes.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30075978-30085377
Strand Forward strand
Band p11.2
Transcripts
ENST00000279387 ENSP00000279387
ENST00000567828
ENST00000563732 ENSP00000455394
ENST00000562664 ENSP00000457089
ENST00000563597 ENSP00000458079
ENST00000561610 ENSP00000455995
ENST00000566749 ENSP00000461609
ENST00000568810
ENST00000567642
ENST00000567040
ENST00000564966
ENST00000563200
ENST00000562222 ENSP00000457915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004704 NF-kappaB-inducing kinase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0016311 dephosphorylation
GO:0038061 NIK/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0030289 protein phosphatase 4 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030697
View Gene Order
ENSBTAG00000012928
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.534338
RefSeq NM_002720 XM_005255418 XM_005255419
HUGO
OMIM
CCDS CCDS10669
HPRD 03615
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca