Version 5.4
Bos taurus Gene: BT.48853
Summary
InnateDB Gene IDBG-639287.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.48853
Gene Name major vault protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007952
Encoded Proteins
IDBP-691434
major vault protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000013364:
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:26661754-26681331
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010451 ENSBTAP00000010451
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0008283 cell proliferation
GO:0023057 negative regulation of signaling
GO:0031953 negative regulation of protein autophosphorylation
GO:0038127 ERBB signaling pathway
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0072376 protein activation cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000013364
View Gene Order
ENSMUSG00000030681
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MNN6
UniProt Splice Variant
Entrez Gene 516456
UniGene Bt.48853
RefSeq NM_001035317
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057900
GenPept
RNA Seq Atlas 516456

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca