InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RELB

Summary

InnateDB Gene

IDBG-639330.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RELB

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000038428

Encoded Proteins

IDBP-691479

v-rel reticuloendotheliosis viral oncogene homolog B

IDBP-691480

v-rel reticuloendotheliosis viral oncogene homolog B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 16951372

[Homo sapiens] RELB is a NF-kappaB subunit that participates in endotoxin tolerance by repressing pro-inflammatory gene expression.

PMID 17823304

[Homo sapiens] RELB mediates transcription of chemokines like IL8 via activation of AHR and Protein kinase A, and its expression is inhibited by Vitamin D3 analog in DCs.

PMID 12657634

[Homo sapiens] RELB acts as both transcription factor as well as a repressor of NF-kappaB gene expression by forming heterodimers with NFKB1 (p50 subunit) and NFKB2 (p100 subunit) or inhibiting RELA DNA binding activity, respectively.

PMID 19020113

[Homo sapiens] RELB sustains NFKBIA (IkappaB alpha) expression during endotoxin tolerance, RelB transcription activation requires binding to the (IkappaB alpha) proximal promoter along with NFKB1 (p50), and is associated with an apparent dimer exchange with RELA (p65).

PMID 19020113

[Homo sapiens] RELB functions as a dual transcription regulator during LPS tolerance and human severe systemic inflammation (SSI) by activating and repressing innate immunity genes.

PMID 21419662

[Homo sapiens] RELB is required for IL17A production in T cell in response to bacterial infection. RELB deficient T cells resulted in a diminished innate immune response to E. coli infection. (Demonstrated in murine model)

PMID 21419662

[Mus musculus] Relb is required for Il17a production in T cell in response to bacterial infection. Relb deficient T cells resulted in a diminished innate immune response to E. coli infection.

PMID 25367573

[Mus musculus] Ripk3 has a novel function in NF-kB activation, dendritic cell biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104856:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:53099825-53127762

Strand

Forward strand

Band

Transcripts

ENSBTAT00000065862	ENSBTAP00000055825
ENSBTAT00000055496	ENSBTAP00000049624

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 118 interaction(s) predicted by orthology.

Predicted by orthology
Total	118 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0010628	positive regulation of gene expression
GO:0019882	antigen processing and presentation
GO:0038061	NIK/NF-kappaB signaling
GO:0042088	T-helper 1 type immune response
GO:0043011	myeloid dendritic cell differentiation
GO:0045063	T-helper 1 cell differentiation