Version 5.4
Bos taurus Gene: RNF40
Summary
InnateDB Gene IDBG-639448.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF40
Gene Name E3 ubiquitin-protein ligase BRE1B
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003421
Encoded Proteins
IDBP-691632
ring finger protein 40
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103549:
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:27140730-27151917
Strand Forward strand
Band
Transcripts
ENSBTAT00000004443 ENSBTAP00000004443
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0010390 histone monoubiquitination
GO:0033523 histone H2B ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0016020 membrane
GO:0033503 HULC complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000103549
View Gene Order
ENSMUSG00000030816
View Gene Order
Cross-References
SwissProt
TrEMBL E1BCI2
UniProt Splice Variant
Entrez Gene 539901
UniGene Bt.21360
RefSeq NM_001206452 XM_005224945
HUGO HGNC:16867
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057908
GenPept
RNA Seq Atlas 539901

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca