Version 5.4
Homo sapiens Gene: RNF40
Summary
InnateDB Gene IDBG-26960.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF40
Gene Name ring finger protein 40, E3 ubiquitin protein ligase
Synonyms BRE1B; RBP95; STARING
Species Homo sapiens
Ensembl Gene ENSG00000103549
Encoded Proteins
IDBP-26964
ring finger protein 40
IDBP-26966
ring finger protein 40
IDBP-751252
IDBP-748621
IDBP-752984
IDBP-808701
ring finger protein 40, E3 ubiquitin protein ligase
IDBP-750584
IDBP-747861
IDBP-808703
ring finger protein 40, E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30761745-30776307
Strand Forward strand
Band p11.2
Transcripts
ENST00000324685 ENSP00000325677
ENST00000357890 ENSP00000350563
ENST00000493683
ENST00000566811 ENSP00000457697
ENST00000563683 ENSP00000455180
ENST00000565995 ENSP00000456538
ENST00000567365 ENSP00000477937
ENST00000566703
ENST00000564260
ENST00000565931 ENSP00000460142
ENST00000563909 ENSP00000455678
ENST00000602784 ENSP00000473507
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
Experimentally validated
Total 53 [view]
Protein-Protein 52 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0017075 syntaxin-1 binding
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010390 histone monoubiquitination
GO:0033523 histone H2B ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0016020 membrane
GO:0033503 HULC complex
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030816
View Gene Order
ENSBTAG00000003421
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.620318 Hs.65238
RefSeq NM_001207033 NM_001207034 NM_001286572 NM_014771
HUGO
OMIM
CCDS CCDS10691 CCDS55994
HPRD 07411
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca