InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GRB7

Summary

InnateDB Gene

IDBG-639472.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRB7

Gene Name

Growth factor receptor-bound protein 7

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017366

Encoded Proteins

IDBP-691646

Growth factor receptor-bound protein 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141738:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:40753903-40762633

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023091

ENSBTAP00000023091

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0019901	protein kinase binding
GO:0035091	phosphatidylinositol binding
GO:0042802	identical protein binding

Biological Process

GO:0007165	signal transduction
GO:0017148	negative regulation of translation
GO:0030335	positive regulation of cell migration
GO:0034063	stress granule assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0030054	cell junction
GO:0042995	cell projection