InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CBS

Summary

InnateDB Gene

IDBG-639589.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBS

Gene Name

cystathionine beta-synthase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000160

Encoded Proteins

IDBP-691770

cystathionine beta-synthase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160200:
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:144790331-144812855

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000184

ENSBTAP00000000184

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004122	cystathionine beta-synthase activity
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0001958	endochondral ossification
GO:0001974	blood vessel remodeling
GO:0006535	cysteine biosynthetic process from serine
GO:0006801	superoxide metabolic process
GO:0019343	cysteine biosynthetic process via cystathionine
GO:0019344	cysteine biosynthetic process
GO:0021587	cerebellum morphogenesis
GO:0030823	regulation of cGMP metabolic process
GO:0043506	regulation of JUN kinase activity
GO:0050667	homocysteine metabolic process
GO:0050880	regulation of blood vessel size
GO:0051593	response to folic acid
GO:0060135	maternal process involved in female pregnancy
GO:0060351	cartilage development involved in endochondral bone morphogenesis