InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: THRA

Summary

InnateDB Gene

IDBG-639592.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THRA

Gene Name

thyroid hormone receptor alpha

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010745

Encoded Proteins

IDBP-691767

thyroid hormone receptor alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126351:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:41017271-41042023

Strand

Forward strand

Band

Transcripts

ENSBTAT00000014236

ENSBTAP00000014236

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002153	steroid receptor RNA activator RNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003727	single-stranded RNA binding
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0017025	TBP-class protein binding
GO:0019904	protein domain specific binding
GO:0031490	chromatin DNA binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0070324	thyroid hormone binding

Biological Process

GO:0001502	cartilage condensation
GO:0001503	ossification
GO:0002155	regulation of thyroid hormone mediated signaling pathway
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007611	learning or memory
GO:0008016	regulation of heart contraction
GO:0008050	female courtship behavior
GO:0009409	response to cold
GO:0009755	hormone-mediated signaling pathway
GO:0009887	organ morphogenesis
GO:0010831	positive regulation of myotube differentiation
GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0030218	erythrocyte differentiation
GO:0030522	intracellular receptor signaling pathway
GO:0030878	thyroid gland development
GO:0033032	regulation of myeloid cell apoptotic process
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0043401	steroid hormone mediated signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045925	positive regulation of female receptivity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050994	regulation of lipid catabolic process
GO:0060509	Type I pneumocyte differentiation
GO:2000143	negative regulation of DNA-dependent transcription, initiation