Version 5.4
Mus musculus Gene: Thra
Summary
InnateDB Gene IDBG-210748.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thra
Gene Name thyroid hormone receptor alpha
Synonyms 6430529J03Rik; AW259572; Erba; Nr1a1; Rvr; T3R[a]; T3Ralpha; Thra1; Thra2
Species Mus musculus
Ensembl Gene ENSMUSG00000058756
Encoded Proteins
IDBP-210750
thyroid hormone receptor alpha
IDBP-210752
thyroid hormone receptor alpha
IDBP-539198
thyroid hormone receptor alpha
IDBP-534340
thyroid hormone receptor alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126351:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:98740638-98769006
Strand Forward strand
Band D
Transcripts
ENSMUST00000103139 ENSMUSP00000099428
ENSMUST00000064187 ENSMUSP00000068281
ENSMUST00000142944
ENSMUST00000153468
ENSMUST00000124130
ENSMUST00000152195
ENSMUST00000153043 ENSMUSP00000123056
ENSMUST00000150693
ENSMUST00000124072 ENSMUSP00000115323
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002153 steroid receptor RNA activator RNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003727 single-stranded RNA binding
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887 thyroid hormone receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0017025 TBP-class protein binding
GO:0019904 protein domain specific binding
GO:0031490 chromatin DNA binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0002155 regulation of thyroid hormone mediated signaling pathway
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007611 learning or memory
GO:0008016 regulation of heart contraction
GO:0008050 female courtship behavior
GO:0009409 response to cold
GO:0009755 hormone-mediated signaling pathway
GO:0009887 organ morphogenesis
GO:0010831 positive regulation of myotube differentiation
GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0030218 erythrocyte differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0030878 thyroid gland development
GO:0033032 regulation of myeloid cell apoptotic process
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043401 steroid hormone mediated signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045925 positive regulation of female receptivity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050994 regulation of lipid catabolic process
GO:0060509 Type I pneumocyte differentiation
GO:2000143 negative regulation of DNA-dependent transcription, initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126351
View Gene Order
ENSBTAG00000010745
Not yet available
Pathways
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P63058
TrEMBL A3KFN7
UniProt Splice Variant
Entrez Gene 21833
UniGene Mm.265917 Mm.451591
RefSeq NM_178060
OMIM
CCDS CCDS25362
HPRD
IMGT
MGI ID MGI:98742
MGI Symbol Thra
EMBL AK078233 AL590963 BC046795 CH466556 X07750 X07751 X07752 X51983
GenPept AAH46795 BAC37186 CAA30575 CAA30576 CAA30577 CAA36241 CAM46188 CAM46189 CAM46190 EDL16164 EDL16165
RNA Seq Atlas 21833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca