Version 5.4
Bos taurus Gene: POFUT2
Summary
InnateDB Gene IDBG-639648.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POFUT2
Gene Name Uncharacterized protein
Synonyms FUT13
Species Bos taurus
Ensembl Gene ENSBTAG00000007818
Encoded Proteins
IDBP-691835
protein O-fucosyltransferase 2
IDBP-691837
protein O-fucosyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186866:
Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:145596461-145610047
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010281 ENSBTAP00000010281
ENSBTAT00000057179 ENSBTAP00000051399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008417 fucosyltransferase activity
GO:0046922 peptide-O-fucosyltransferase activity
Biological Process
GO:0001707 mesoderm formation
GO:0010468 regulation of gene expression
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0036065 fucosylation
GO:0036066 protein O-linked fucosylation
GO:0051046 regulation of secretion
Cellular Component
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000186866
View Gene Order
ENSMUSG00000020260
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
REACT_211817
O-glycosylation of TSR domain-containing proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_204003
O-linked glycosylation pathway
KEGG
hsa00514
Other types of O-glycan biosynthesis pathway
mmu00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MPI4
UniProt Splice Variant
Entrez Gene 404083
UniGene Bt.7147
RefSeq XM_005202007
HUGO HGNC:14683
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003435
GenPept
RNA Seq Atlas 404083

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca