Version 5.4
Mus musculus Gene: Pofut2
Summary
InnateDB Gene IDBG-166806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pofut2
Gene Name protein O-fucosyltransferase 2
Synonyms 2310011G23Rik; AI256847; BC003494; C21orf80; FUT13
Species Mus musculus
Ensembl Gene ENSMUSG00000020260
Encoded Proteins
IDBP-166808
protein O-fucosyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186866:
Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:77259300-77269586
Strand Forward strand
Band C1
Transcripts
ENSMUST00000020493 ENSMUSP00000020493
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008417 fucosyltransferase activity
GO:0046922 peptide-O-fucosyltransferase activity
Biological Process
GO:0001707 mesoderm formation
GO:0006004 fucose metabolic process
GO:0010468 regulation of gene expression
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0036065 fucosylation
GO:0036066 protein O-linked fucosylation
GO:0051046 regulation of secretion
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186866
View Gene Order
ENSBTAG00000007818
Not yet available
Pathways
NETPATH
REACTOME
REACT_211817
O-glycosylation of TSR domain-containing proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_204003
O-linked glycosylation pathway
KEGG
mmu00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
hsa00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q8VHI3
TrEMBL B2RV73
UniProt Splice Variant
Entrez Gene 80294
UniGene Mm.203556 Mm.410279
RefSeq NM_030262
OMIM
CCDS CCDS23954
HPRD
IMGT
MGI ID MGI:1916863
MGI Symbol Pofut2
EMBL AF455270 AK009301 BC018194 BC147077 BC147078 CH466553
GenPept AAI47078 AAI47079 AAL65192 BAB26202 EDL31818
RNA Seq Atlas 80294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca