InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TOP2A

Summary

InnateDB Gene

IDBG-639659.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOP2A

Gene Name

topoisomerase (DNA) II alpha 170kDa

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019262

Encoded Proteins

IDBP-691885

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131747:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:41281652-41307194

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061367

ENSBTAP00000053858

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003916	DNA topoisomerase activity
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008094	DNA-dependent ATPase activity
GO:0008144	drug binding
GO:0008301	DNA binding, bending
GO:0016853	isomerase activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043130	ubiquitin binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0000819	sister chromatid segregation
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change
GO:0006266	DNA ligation
GO:0006268	DNA unwinding involved in DNA replication
GO:0006312	mitotic recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0007059	chromosome segregation
GO:0030261	chromosome condensation
GO:0030263	apoptotic chromosome condensation
GO:0040016	embryonic cleavage
GO:0043065	positive regulation of apoptotic process
GO:0044774	mitotic DNA integrity checkpoint
GO:0045070	positive regulation of viral genome replication
GO:0045870	positive regulation of retroviral genome replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000228	nuclear chromosome
GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005814	centriole
GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)
GO:0043234	protein complex