Version 5.4
Bos taurus Gene: DNMT3L
Summary
InnateDB Gene IDBG-639668.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNMT3L
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014882
Encoded Proteins
IDBP-691852
DNA (cytosine-5-)-methyltransferase 3-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142182:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:145703698-145718149
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019812 ENSBTAP00000019812
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008047 enzyme activator activity
Biological Process
GO:0001701 in utero embryonic development
GO:0001890 placenta development
GO:0032259 methylation
GO:0060718 chorionic trophoblast cell differentiation
GO:0071514 genetic imprinting
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005720 nuclear heterochromatin
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000142182
View Gene Order
ENSMUSG00000000730
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_267652
DNA methylation pathway
REACT_71
Gene Expression pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_233572
Gene Expression pathway
REACT_268475
DNA methylation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N0W8
UniProt Splice Variant
Entrez Gene 613785
UniGene Bt.101516
RefSeq XM_002685135 XM_864897
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003437
GenPept
RNA Seq Atlas 613785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca