InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dnmt3l

Summary

InnateDB Gene

IDBG-168381.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnmt3l

Gene Name

DNA (cytosine-5-)-methyltransferase 3-like

Synonyms

D6Ertd14e; ecat7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000730

Encoded Proteins

IDBP-168383

DNA (cytosine-5-)-methyltransferase 3-like

IDBP-538196

DNA (cytosine-5-)-methyltransferase 3-like

IDBP-538622

DNA (cytosine-5-)-methyltransferase 3-like

IDBP-534805

DNA (cytosine-5-)-methyltransferase 3-like

IDBP-538677

DNA (cytosine-5-)-methyltransferase 3-like

IDBP-532443

DNA (cytosine-5-)-methyltransferase 3-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142182:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:78041947-78063622

Strand

Forward strand

Band

Transcripts

ENSMUST00000000746	ENSMUSP00000000746
ENSMUST00000135316
ENSMUST00000138785	ENSMUSP00000121562
ENSMUST00000151242	ENSMUSP00000116970
ENSMUST00000144446
ENSMUST00000131825	ENSMUSP00000119571
ENSMUST00000139539	ENSMUSP00000117827
ENSMUST00000123940	ENSMUSP00000123015

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0032259	methylation
GO:0043085	positive regulation of catalytic activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060718	chorionic trophoblast cell differentiation
GO:0071514	genetic imprinting

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005720	nuclear heterochromatin
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000142182

View Gene Order

ENSBTAG00000014882

Not yet available

Pathways

NETPATH

REACTOME

REACT_205737

Epigenetic regulation of gene expression pathway

REACT_233572

Gene Expression pathway

REACT_268475

DNA methylation pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_200857

Epigenetic regulation of gene expression pathway

REACT_267652

DNA methylation pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.13433

RefSeq

NM_001081695 NM_001284197 NM_001284198 NM_001284199 NM_001284200 NM_019448

OMIM

CCDS

CCDS23962 CCDS70061

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas