Version 5.4
Bos taurus Gene: A2M
Summary
InnateDB Gene IDBG-639675.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A2M
Gene Name Alpha-2-macroglobulin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018137
Encoded Proteins
IDBP-691873
Alpha-2-macroglobulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175899:
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:101298127-101346611
Strand Forward strand
Band
Transcripts
ENSBTAT00000006167 ENSBTAP00000006167
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 81 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019838 growth factor binding
GO:0019899 enzyme binding
GO:0019959 interleukin-8 binding
GO:0019966 interleukin-1 binding
GO:0030414 peptidase inhibitor activity
GO:0043120 tumor necrosis factor binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001869 negative regulation of complement activation, lectin pathway
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0048863 stem cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000175899
View Gene Order
ENSMUSG00000030111
View Gene Order
Pathways
NETPATH
REACTOME
REACT_202252
Platelet degranulation pathway
REACT_223425
Extracellular matrix organization pathway
REACT_212432
Lipoprotein metabolism pathway
REACT_206454
Intrinsic Pathway pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_201925
Degradation of the extracellular matrix pathway
REACT_211150
Rho GTPase cycle pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_222480
HDL-mediated lipid transport pathway
REACT_214353
Signal Transduction pathway
REACT_209608
Signaling by Rho GTPases pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_217138
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_213267
Lipid digestion, mobilization, and transport pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_326
Intrinsic Pathway pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_11051
Rho GTPase cycle pathway
REACT_13621
HDL-mediated lipid transport pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_118779
Extracellular matrix organization pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_6823
Lipoprotein metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_604
Hemostasis pathway
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_213857
HDL-mediated lipid transport pathway
REACT_188937
Metabolism pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_239392
Intrinsic Pathway pathway
REACT_235097
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_211709
Lipoprotein metabolism pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
mmu04610
Complement and coagulation cascades pathway
INOH
PID NCI
il6_7pathway
IL6-mediated signaling events
Cross-References
SwissProt Q7SIH1
TrEMBL
UniProt Splice Variant
Entrez Gene 513856
UniGene Bt.60794
RefSeq NM_001109795 XM_005207056
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC153840
GenPept AAI53841
RNA Seq Atlas 513856

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca