Mus musculus Gene: A2m
Summary
InnateDB Gene IDBG-184734.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A2m
Gene Name alpha-2-macroglobulin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030111
Encoded Proteins
alpha-2-macroglobulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175899:
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:121636173-121679237
Strand Forward strand
Band F1
Transcripts
ENSMUST00000032203 ENSMUSP00000032203
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.
Predicted by orthology
Total 86 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019838 growth factor binding
GO:0019899 enzyme binding
GO:0019959 interleukin-8 binding
GO:0019966 interleukin-1 binding
GO:0030414 peptidase inhibitor activity
GO:0043120 tumor necrosis factor binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001869 negative regulation of complement activation, lectin pathway
GO:0007565 female pregnancy
GO:0010951 negative regulation of endopeptidase activity
GO:0048863 stem cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Hemostasis pathway
HDL-mediated lipid transport pathway
Metabolism pathway
Extracellular matrix organization pathway
Platelet activation, signaling and aggregation pathway
Metabolism of lipids and lipoproteins pathway
Intrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Lipid digestion, mobilization, and transport pathway
Signaling by Rho GTPases pathway
Rho GTPase cycle pathway
Lipoprotein metabolism pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signal Transduction pathway
Degradation of the extracellular matrix pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Intrinsic Pathway pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Rho GTPase cycle pathway
HDL-mediated lipid transport pathway
Metabolism of lipids and lipoproteins pathway
Extracellular matrix organization pathway
Signaling by Rho GTPases pathway
Degradation of the extracellular matrix pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Lipoprotein metabolism pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Hemostasis pathway
Platelet degranulation pathway
Extracellular matrix organization pathway
Lipoprotein metabolism pathway
Intrinsic Pathway pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Degradation of the extracellular matrix pathway
Rho GTPase cycle pathway
Response to elevated platelet cytosolic Ca2+ pathway
HDL-mediated lipid transport pathway
Signal Transduction pathway
Signaling by Rho GTPases pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Lipid digestion, mobilization, and transport pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID NCI
IL6-mediated signaling events
Cross-References
SwissProt Q6GQT1
TrEMBL
UniProt Splice Variant
Entrez Gene 232345
UniGene Mm.30151
RefSeq NM_175628
OMIM
CCDS CCDS39617
HPRD
IMGT
MGI ID MGI:2449119
MGI Symbol A2m
EMBL AC153581 AY185125 BC072642
GenPept AAH72642 AAO25741
RNA Seq Atlas 232345