InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SMC3

Summary

InnateDB Gene

IDBG-639676.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMC3

Gene Name

structural maintenance of chromosomes protein 3

Synonyms

CSPG6; SMC-3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013905

Encoded Proteins

IDBP-691899

structural maintenance of chromosomes protein 3

IDBP-691903

structural maintenance of chromosomes protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108055:
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:31387332-31425414

Strand

Forward strand

Band

Transcripts

ENSBTAT00000046231	ENSBTAP00000043550
ENSBTAT00000063829	ENSBTAP00000056339

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	93 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0036033	mediator complex binding
GO:0045502	dynein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006275	regulation of DNA replication
GO:0007052	mitotic spindle organization
GO:0007126	meiotic nuclear division
GO:0007165	signal transduction
GO:0019827	stem cell maintenance
GO:0032876	negative regulation of DNA endoreduplication
GO:0051276	chromosome organization

Cellular Component

GO:0000785	chromatin
GO:0000800	lateral element
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0030893	meiotic cohesin complex
GO:0034991	nuclear meiotic cohesin complex