InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SMC3

Summary

InnateDB Protein

IDBP-691899.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMC3

Protein Name

structural maintenance of chromosomes protein 3

Synonyms

CSPG6; SMC-3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000043550

InnateDB Gene

IDBG-639676 (SMC3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	93 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0036033	mediator complex binding
GO:0045502	dynein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006275	regulation of DNA replication
GO:0007052	mitotic spindle organization
GO:0007126	meiotic nuclear division
GO:0007165	signal transduction
GO:0019827	stem cell maintenance
GO:0032876	negative regulation of DNA endoreduplication
GO:0051276	chromosome organization

Cellular Component

GO:0000785	chromatin
GO:0000800	lateral element
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0030893	meiotic cohesin complex
GO:0034991	nuclear meiotic cohesin complex

Protein Structure and Domains

PDB ID

InterPro

IPR003395 RecF/RecN/SMC, N-terminal
IPR010935 SMCs flexible hinge
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02463
PF06470

PRINTS

PIRSF

SMART

SM00968

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A7Z065

UniProt Splice Variant

Entrez Gene

281729

UniGene

Bt.5290

RefSeq

NP_776720

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC153263 DAAA02059205

GenPept

AAI53264