Version 5.4
Bos taurus Gene: PHC1
Summary
InnateDB Gene IDBG-639701.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHC1
Gene Name polyhomeotic-like protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018205
Encoded Proteins
IDBP-691907
polyhomeotic homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111752:
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:101453054-101472170
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024230 ENSBTAP00000024230
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0016574 histone ubiquitination
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0016604 nuclear body
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111752
View Gene Order
ENSMUSG00000040669
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BHH0
UniProt Splice Variant
Entrez Gene 540021
UniGene Bt.61366
RefSeq NM_001205756 XM_005207070 XM_005207072 XM_005207073
HUGO HGNC:3182
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014388
GenPept
RNA Seq Atlas 540021

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca